Female mice are protected from impaired parenchymal arteriolar TRPV4 function and impaired cognition in hypertension
Laura C. Chambers, Martina Yen, William F. Jackson, Anne M. Dorrance
Abstract
Vascular dementia is a significant public health concern, and the effect of biological sex on dementia development is not well understood. TRPV4 channels are essential regulators of cerebral parenchymal arteriolar function and cognition. Hypertension impairs TRPV4-mediated dilation and memory in male rodents. Data presented here suggest female sex protects against impaired TRPV4 dilation and cognitive dysfunction during hypertension. These data advance our understanding of the influence of biological sex on cerebrovascular health in hypertension.
Topics & Concepts
CognitionImpaired renal functionTRPV4NeuroscienceMedicineInternal medicinePsychologyRenal functionTransient receptor potential channelReceptorCardiovascular, Neuropeptides, and Oxidative Stress ResearchRenin-Angiotensin System StudiesHormonal Regulation and Hypertension