A microfluidic co-culture model for investigating colonocytes–microbiota interactions in colorectal cancer
Daniel Penarete-Acosta, Rachel Stading, Laura Emerson, Mitchell Horn, Sanjukta Chakraborty, Arum Han, Arul Jayaraman
Abstract
significantly altered the abundance of multiple bacterial clades associated with mucosal immune responses and cancer development in the colon. Our results highlight the importance of evaluating the potential carcinogenic activity of pathogens in the context of a commensal microbiota, and the potential to discover novel inter-species microbial interactions in the CRC microenvironment.
Topics & Concepts
Colorectal cancerMicrofluidicsCancerCancer researchComputational biologyNanotechnologyBiologyMaterials scienceGeneticsGut microbiota and health3D Printing in Biomedical ResearchClostridium difficile and Clostridium perfringens research