Synthesis of 4-trifluoromethyl pyridazines <i>via</i> annulation of pyridinium ylides with trifluoroacetyl diazoester
Zheng Fang, Yun Teng, Yang Huilin, Rongxing Li, Qiuhong Li, Yi You, Zhiqiang Weng
Abstract
A base promoted annulation of pyridinium ylides with trifluoroacetyl diazoester for the synthesis of 4-trifluoromethyl pyridazines has been developed.
Topics & Concepts
AnnulationPyridiniumTrifluoromethylChemistryMedicinal chemistryOrganic chemistryCatalysisAlkylFluorine in Organic ChemistryCyclopropane Reaction MechanismsSynthesis and Reactions of Organic Compounds