Human papillomavirus 42–associated digital papillary adenocarcinoma

Abstract

Digital papillary adenocarcinoma (DPAc) is a rare malignant tumor of the eccrine sweat glands. It presents most often as a slowly growing, deeply seeded nodule on the distal extremities. If left untreated, recurrence rates are high and metastatic potential is significant, making this tumor especially aggressive.1,2 Although the etiology of DPAc is largely unknown, a recent study has documented an association of this tumor with human papillomavirus (HPV)-42.3 In this report, we discuss a case of DPAc with positive HPV-42 hybridization signaling.

Topics & Concepts