Species Distribution and Antifungal Susceptibilities of <i>Aspergillus</i> Section <i>Fumigati</i> Isolates in Clinical Samples from the United States
Hamid Badali, Connie Cañete‐Gibas, Dora I. McCarthy, Hoja Patterson, Carmita Sanders, Marjorie David, James Mele, Hongxin Fan, Nathan P. Wiederhold
Abstract
Aspergillus species are capable of causing both invasive disease and chronic infections in immunocompromised patients or those with preexisting lung conditions. Aspergillus fumigatus is the most commonly cultured species, and there is increasing concern regarding resistance to the azoles, which are the mainstays of antifungal therapy against aspergillosis. We evaluated the species distribution and susceptibility profiles of isolates within Aspergillus section Fumigati in the United States over a 52-month period.
Topics & Concepts
PosaconazoleVoriconazoleBiologyMicrobiologyAspergillusAspergillus fumigatusBroth microdilutionAmphotericin BAspergillosisAzoleMinimum inhibitory concentrationAntibioticsAntifungalImmunologyAntifungal resistance and susceptibilityFungal Infections and StudiesInfectious Diseases and Mycology