Aerial Oxidation of Phenol/Catechol in the Presence of Catalytic Amounts of [(Cl)2Mn(RCOOET)], RCOOET= Ethyl-5-Methyl-1-(((6-Methyl-3-Nitropyridin-2-yl)Amino)Methyl)-1H-Pyrazole-3-Carboxylate
Mohamed El Boutaybi, Abderrahim Titi, Abdullah Yahya Abdullah Alzahrani, Zahra Bahari, Monique Tillard, B. Hammouti, Rachid Touzani
Abstract
In this work, we report on the catalytic activity of a manganese complex [(Cl)2Mn(RCOOET)], where RCOOET is ethyl-5-methyl-1-(((6-methyl-3-nitropyridin-2-yl)amino)methyl)-1H-pyrazole-3-carboxylate, in the oxidation of phenol or catechol by atmospheric oxygen to form o-quinone. The [(Cl)2Mn(RCOOET)] catalyzes the oxidation of catechol at a rate of 3.74 µmol L−1 min−1 in tetrahydrofuran (THF), in a similar manner to catecholase or tyrosinase.
Topics & Concepts
CatecholChemistryPhenolTetrahydrofuranPyrazoleCarboxylateCatalysisMedicinal chemistryStereochemistryOrganic chemistrySolventMetal-Catalyzed Oxygenation MechanismsAntioxidant Activity and Oxidative StressFree Radicals and Antioxidants