Association of Clinical, Tumor, and Treatment Characteristics With Seizure Control in Patients With <i>IDH1/2</i> -Mutant Lower-Grade Glioma
Francesco Bruno, Alessia Pellerino, Marco Conti Nibali, Edoardo Pronello, Fabio Cofano, Marco Rossi, Mario Levis, Luca Bertero, Riccardo Soffietti, Paola Cassoni, Diego Garbossa, Lorenzo Bello, Roberta Rudà
Abstract
BACKGROUND AND OBJECTIVES: -mutant lower-grade glioma have a high frequency of seizures. We aimed to investigate the correlations between seizures and tumor/patient characteristics and the impact of surgery and adjuvant treatments (AT) on seizure control along the disease trajectory. METHODS: homozygous deletion, intense/ring contrast enhancement on MRI at presentation, and small tissue biopsy. We evaluated seizure freedom for 2 months after surgery, 6 months from starting observation or AT, at recurrence, and for 6 months after treatments of recurrence. RESULTS: = 0.037). DISCUSSION: -mutant lower-grade glioma.