Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment
Lei Wang, Lin Zhao, Fu‐Lian Gong, Chao Sun, Dandan Du, Xiaoxia Yang, Xiuli Guo
Topics & Concepts
Tumor microenvironmentCancer researchBreast cancerMacrophage polarizationTumor-associated macrophageMetastasisSTAT3Hypoxia (environmental)MedicineTumor necrosis factor alphaTumor progressionChemistryCancerInternal medicineIn vitroMacrophageApoptosisTumor cellsBiochemistryOxygenOrganic chemistryImmune cells in cancerAutophagy in Disease and TherapyImmune Cell Function and Interaction