Vectored antibody gene delivery restores host B and T cell control of persistent viral infection
Yusuf I. Ertuna, Bénédict Fallet, Anna‐Friederike Marx, Mirela Dimitrova, Anna Lena Kastner, Ingrid Wagner, Doron Merkler, Daniel D. Pinschewer
Abstract
T cells. These results indicate that VAGD fortifies host immune defense and synergizes with B cell and CD8 T cell responses to restore immune control of chronic viral infection.
Topics & Concepts
Lymphocytic choriomeningitisBiologyVirologyAntibodyImmune systemVirusNeutralizing antibodyGerminal centerImmunologyCD8Viral vectorT cellB cellGeneRecombinant DNABiochemistryVirus-based gene therapy researchViral gastroenteritis research and epidemiologyCAR-T cell therapy research