Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection
William T. Yewdell, Ryan Smolkin, Kalina T. Belcheva, Alejandra Mendoza, Anthony Michaels, Montserrat Cols, Davide Angeletti, Jonathan W. Yewdell, Jayanta Chaudhuri
Abstract
MBCs to the long-lived compartment. Our findings highlight critical aspects of persistent GC responses and MBC differentiation following respiratory virus infection with direct implications for developing effective vaccination strategies.
Topics & Concepts
Germinal centerBiologyImmunologyVirusVirologyImmunizationSpleenHemagglutinin (influenza)VaccinationB cellMemory B cellInfluenza A virusLymph nodeImmune systemAntibodyT-cell and B-cell ImmunologyImmune Cell Function and InteractionImmunotherapy and Immune Responses