Impact of microchannel width on axons for brain-on-chip applications
Katarina Vulić, Giulia Amos, Tobias Ruff, Revan Kasm, Stephan J. Ihle, Joël Küchler, János Vörös, Sean Weaver
Abstract
Axon growth is influenced by the width and number of microchannels, with growth cone adaptability reaching its limit for constraints smaller than 350 nm. Tradeoffs between axon growth and control need to be made for neurofluidic devices.
Topics & Concepts
AxonMicrochannelAdaptabilityLimit (mathematics)ChipAxon guidanceGrowth coneMaterials scienceNanotechnologyOptoelectronicsNeuroscienceEngineeringBiologyElectrical engineeringMathematicsEcologyMathematical analysisNeuroscience and Neural Engineering3D Printing in Biomedical ResearchAdvanced Memory and Neural Computing