Discovery of potent 1,1-diarylthiogalactoside glycomimetic inhibitors of Pseudomonas aeruginosa LecA with antibiofilm properties
Alexandre Bruneau, Émilie Gillon, Aurélie Furiga, Etienne Brachet, Mouâd Alami, Christine Roques, Annabelle Varrot, Anne Imberty, Samir Messaoudi
Topics & Concepts
ChemistryPseudomonas aeruginosaBiofilmLigand (biochemistry)BenzophenoneDivalentVirulence factorStructure–activity relationshipSortase ABiological activityStereochemistryVirulenceBiochemistryMicrobiologyBacteriaReceptorIn vitroOrganic chemistryBacterial proteinBiologyGeneGeneticsBiochemical and Structural CharacterizationBacteriophages and microbial interactionsBacterial biofilms and quorum sensing