<i>ipso</i>-Cyclization of unactivated biaryl ynones leading to thio-functionalized spirocyclic enones
Chada Raji Reddy, Uprety Ajaykumar, Amol D. Patil, Remya Ramesh
Abstract
) to access spiro[5,5]trienones has been established. This approach displayed excellent regioselectivity towards spirocyclization and tolerated a variety of functional groups. Dearomatization of hitherto unknown aryl/heteroaryl groups is also disclosed. DMSO is employed as a low-toxicity, inexpensive solvent as well as a source of oxygen.
Topics & Concepts
ChemistryThio-Combinatorial chemistryStereochemistrySulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsRadical Photochemical Reactions