Activation of the alternative complement pathway modulates inflammation in thoracic aortic aneurysm/dissection
Chunmei Piao, Wenmei Zhang, Jing Deng, Mei Zhou, Tingting Liu, Shuai Zheng, Lixin Jia, Wen‐Chao Song, Yan Liu, Jie Du
Abstract
The alternative complement pathway promoted the development of TAAD by recruiting infiltrating inflammatory cells. Targeting the alternative pathway may thus constitute a strategy for preventing the development of TAAD.
Topics & Concepts
Thoracic aortic aneurysmInflammationAortic aneurysmMedicineComplement systemComplement (music)Aortic dissectionAneurysmAlternative complement pathwayDissection (medical)CardiologyInternal medicineSurgeryImmunologyAortaBiologyImmune systemGeneComplementationPhenotypeBiochemistryComplement system in diseasesKawasaki Disease and Coronary ComplicationsBlood Coagulation and Thrombosis Mechanisms