Meclizine and Metabotropic Glutamate Receptor Agonists Attenuate Severe Pain and Ca <sup>2+</sup> Activity of Primary Sensory Neurons in Chemotherapy-Induced Peripheral Neuropathy
John Shannonhouse, Matteo Bernabucci, Ruben Gomez, Hyeonwi Son, Yan Zhang, Chih-Hsuan Ai, Hirotake Ishida, Yu Shin Kim
Abstract
activity and reduces pain hypersensitivity. Our results and experiments provide insights into cellular effects of cisplatin and drugs preventing CIPN pain.
Topics & Concepts
Metabotropic glutamate receptorAgonistPharmacologyMedicineGlutamate receptorMetabotropic receptorAntagonistPeripheral neuropathyMetabotropic glutamate receptor 5Neuropathic painDorsal root ganglionNeuroprotectionAnesthesiaInternal medicineSensory systemReceptorEndocrinologyNeurosciencePsychologyDiabetes mellitusCancer Treatment and PharmacologyPain Mechanisms and TreatmentsSynthesis and pharmacology of benzodiazepine derivatives