Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer
Hui Luo, Qi Zhao, Wei Wei, Lianghong Zheng, Shaohua Yi, Gen Li, Wenqiu Wang, Hui Sheng, Heng‐Ying Pu, Hai‐Yu Mo, Zhixiang Zuo, Zexian Liu, Chaofeng Li, Chuanbo Xie, Zhao-Lei Zeng, Weimin Li, Xiaoke Hao, Yuying Liu, Su‐Mei Cao, Wanli Liu, Sarah Gibson, Kang Zhang, Guoliang Xu, Rui‐Hua Xu
Abstract
= 0.011 in validation cohort). Last, we found that a single ctDNA methylation marker, cg10673833, could yield high sensitivity (89.7%) and specificity (86.8%) for detection of CRC and precancerous lesions in a high-risk population of 1493 participants in a prospective cohort study. Together, our findings showed the value of ctDNA methylation markers in the diagnosis, surveillance, and prognosis of CRC.
Topics & Concepts
DNA methylationColorectal cancerMethylationCancerMedicineCancer researchOncologyCirculating tumor DNADNAInternal medicineBioinformaticsBiologyGeneGeneticsGene expressionCancer Genomics and DiagnosticsEpigenetics and DNA MethylationFerroptosis and cancer prognosis