Host Genome-Wide Association Study of Infant Susceptibility to<i>Shigella</i>-Associated Diarrhea
Dylan Duchen, Rashidul Haque, Laura Chen, Genevieve L. Wojcik, Poonum Korpe, Uma Nayak, Alexander J. Mentzer, Beth D. Kirkpatrick, William A. Petri, Priya Duggal
Abstract
Shigella is a leading cause of moderate-to-severe diarrhea globally and the causative agent of shigellosis and bacillary dysentery. Associated with 80 to 165 million cases of diarrhea and >13% of diarrheal deaths, in many regions, Shigella exposure is ubiquitous while infection is heterogenous.
Topics & Concepts
ShigellosisShigellaDiarrheaBacillary dysenteryDysenteryBiologyDiarrheal diseaseDiarrheal diseasesMicrobiologyShigella flexneriVirologyMedicineSalmonellaBacteriaGeneticsInternal medicineEscherichia coliGeneEscherichia coli research studiesViral gastroenteritis research and epidemiologyGut microbiota and health