Reusable Magnetic Nanoparticles: A Green System for Synthesis of Pyrrole Scaffolds
Shubham Sharma, Vaishali Vaishali, Aaysha Pandey, Ayushi Garg, Pooja Sharma, Kanchna Bhatrola, Ali Irfan, Nisha Devi, Laila Rubab, Kaushiki Mishra, Khushali Dubey, Emilio Mateev
Abstract
ABSTRACT Nowadays, environmentally sustainable organic synthesis is demanding. In this context, nanoparticles are particularly interesting owing to their green synthesis aspects. Specifically, magnetic nanoparticles have been continuously utilized in organic synthesis for a decade. Among heterocycles, pyrrole and its analogs have a unique place due to its vast spectrum of applications. Derivatives of pyrrole help to find lead structures for new synthetic pharmaceutical compounds and other valuable compounds. Thus, magnetic nanoparticles accelerate organic chemists to develop pyrrole derivatives through green synthesis. Moreover, magnetic nanoparticles in pyrrole scaffold synthesis improve reaction efficiency and sustainability and create unique functional molecular hybrids for many scientific applications. This paper reviews the utilization of magnetic nanoparticles to afford a variety of valuable pyrrole derivatives, with a focus on their environmental friendliness.