Phorbol ester activates human mesenchymal stem cells to inhibit B cells and ameliorate lupus symptoms in MRL.<i>Fas</i><sup>lpr</sup> mice
Hong Kyung Lee, Hyung Sook Kim, Minji Pyo, Eun Jae Park, Sundong Jang, Hye Won Jun, Tae Yong Lee, Kyung Suk Kim, Sang‐Cheol Bae, Youngsoo Kim, Jin Tae Hong, Jaesuk Yun, Sang‐Bae Han
Abstract
Taken together, our data demonstrate that phorbol esters might be good tool compounds to activate MSCs to inhibit B cells and suggest that our chemical approach might allow for improvements in the therapeutic efficacy of hMSCs in SLE.
Topics & Concepts
Mesenchymal stem cellStem cellChemistryCancer researchSystemic lupus erythematosusMolecular biologyCell biologyImmunologyPharmacologyMedicineBiologyPathologyDiseaseMesenchymal stem cell researchMicroRNA in disease regulationOsteoarthritis Treatment and Mechanisms