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Discovery and identification of a novel PI3K inhibitor with enhanced CDK2 inhibition for the treatment of triple negative breast cancer

Chengbin Yang, Menghui Wang, Yimin Gong, Mingli Deng, Yun Ling, Qingquan Li, Jianxin Wang, Yaming Zhou, Yaming Zhou

2023Bioorganic Chemistry17 citationsDOI

Topics & Concepts

Triple-negative breast cancerChemistryPI3K/AKT/mTOR pathwayCancer researchKinaseGrowth inhibitionApoptosisBreast cancerCancerPharmacologyBiochemistryBiologyInternal medicineMedicineAdvanced Breast Cancer TherapiesCancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer
Discovery and identification of a novel PI3K inhibitor with enhanced CDK2 inhibition for the treatment of triple negative breast cancer | Litcius