The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1
Kifayat Ullah, Suping Chen, Jiaqi Lü, Xiaohui Wang, Qing Liu, Yang Zhang, Ya‐Qiu Long, Zhanhong Hu, Guoqiang Xu
Abstract
knockdown diminishes this effect, and BMAL1 overexpression abolishes STUB1's effect on cell senescence. In summary, the results of our work reveal that the E3 ubiquitin ligase STUB1 ubiquitinates and degrades its substrate BMAL1 and thereby alleviates hydrogen peroxide-induced cell senescence.
Topics & Concepts
Ubiquitin ligaseUbiquitinRegulatorCircadian clockCell biologyDegronUbiquitin-Protein LigasesSenescenceProtein degradationBiologyCircadian rhythmChemistryBiochemistryEndocrinologyGeneCircadian rhythm and melatoninTelomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms