Long-term physical inactivity exacerbates hindlimb unloading-induced muscle atrophy in young rat soleus muscle
Toshinori Yoshihara, Toshiharu Natsume, Takamasa Tsuzuki, Shuo-wen Chang, Ryo Kakigi, Shuichi Machida, Takao Sugiura, Hisashi Naıto
Abstract
Long-term physical inactivity exacerbates hindlimb unloading-induced disuse muscle atrophy in young rat soleus muscles, possibly mediated by oxidative stress-induced protein ubiquitination via HDAC4- and NF-κB p65-induced MuRF1 mRNA upregulation.
Topics & Concepts
HindlimbSoleus muscleDownregulation and upregulationMuscle atrophyAtrophyEndocrinologyInternal medicineOxidative stressUbiquitinChemistrySkeletal muscleBiologyMedicineBiochemistryGeneMuscle Physiology and DisordersAdipose Tissue and MetabolismMuscle metabolism and nutrition