FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis
Nobuhiro Tanno, Kazumasa Takemoto, Yuki Takada-Horisawa, Ryuki Shimada, Sayoko Fujimura, Naoki Tani, Naoki Takeda, Kimi Araki, Kei‐ichiro Ishiguro
Abstract
KO spermatocytes remain in an earlier stage of meiotic prophase I and lack crossovers, despite apparently exhibiting diplotene-like chromosome morphology. We propose that FBXO47 plays a crucial role in preventing the synaptonemal complex from premature disassembly during cell cycle progression of meiotic prophase I.
Topics & Concepts
SynapsisSynaptonemal complexMeiosisHomologous chromosomeProphaseBiologyChromosomal crossoverBivalent (engine)Homologous recombinationGeneticsCell biologyChromosome segregationChromosomeChemistryDNAGeneOrganic chemistryMetalDNA Repair MechanismsMitochondrial Function and PathologyGenomics and Chromatin Dynamics