Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity
Mostafa M. Elbadawi, Wagdy M. Eldehna, Wenjie Wang, Keli Agama, Yves Pommier, Manabu Abe
Topics & Concepts
ChemistryTopoisomeraseCamptothecinLinkerStereochemistryIn vitroCell cultureCytotoxicityArylCancer cellMelanomaCancerBiochemistryCancer researchBiologyComputer scienceOperating systemAlkylOrganic chemistryGeneticsCancer therapeutics and mechanismsSynthesis and Biological EvaluationLung Cancer Research Studies