Copper‐Catalyzed Enantioselective Sonogashira Type Coupling of Alkynes with α‐Bromoamides
Xueling Mo, Bin Chen, Guozhu Zhang
Abstract
Abstract An asymmetric copper‐catalyzed Sonogashira type coupling between alkynes and α‐bromoamides has been developed. This method represents a facile approach to synthetically useful β, γ‐alkynyl amides from two readily available starting materials in a highly enantioselective manner. A Bisoxazoline diphenylanaline (BOPA) serves as the effective chiral ligand. Preliminary mechanistic studies support the formation of alkyl radical species .
Topics & Concepts
Sonogashira couplingEnantioselective synthesisCombinatorial chemistryChemistryCatalysisLigand (biochemistry)CopperAlkylCoupling (piping)Organic chemistryPalladiumMaterials scienceReceptorMetallurgyBiochemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsRadical Photochemical Reactions