Quorum Sensing Promotes Phage Infection in Pseudomonas aeruginosa PAO1
Guanhua Xuan, Hong Lin, Lin Tan, Gang Zhao, Jingxue Wang
Abstract
, which is necessary for the synthesis of phage receptor lipopolysaccharides. In contrast to the results of previous reports, we showed that QS increases the efficacy of phage-mediated bacterial killing. Since QS upregulates the expression of virulence factors and promotes biofilm development, which are positively correlated with lipopolysaccharide production in P. aeruginosa, increased phage susceptibility is a novel QS-mediated trade-off. QS inhibition may increase the efficacy of antibiotic treatment, but it will reduce the effectiveness of phage therapy.
Topics & Concepts
Pseudomonas aeruginosaPhage therapyVirulenceQuorum sensingMicrobiologyBiofilmBacteriaLipopolysaccharideBiologyPhagemidBacteriophageChemistryGeneEscherichia coliImmunologyGeneticsBacteriophages and microbial interactionsBacterial biofilms and quorum sensingBacterial Genetics and Biotechnology