Discovery of thiapyran-pyrimidine derivatives as potential EGFR inhibitors
Zhen Xiao, Cilong Chu, Lingjia Zhou, Zhihui Zhou, Qian Zhang, Feiyi Yang, Zunhua Yang, Pengwu Zheng, Shan Xu, Wufu Zhu
Topics & Concepts
ChemistryApoptosisCell culturePyrimidineCell cycleA549 cellStructure–activity relationshipKinaseCell cycle checkpointCellBiochemistryCell growthLead compoundCancer cellIn vitroCancerBiologyGeneticsSynthesis and biological activityCancer therapeutics and mechanismsLung Cancer Treatments and Mutations