Towards <sup>213</sup>Bi alpha-therapeutics and beyond: unravelling the foundations of efficient Bi<sup>III</sup> complexation by DOTP
David Horváth, Fabio Travagin, N. Guidolin, Federica Buonsanti, Gyula Tircsó, Imre Tóth, Frank Bruchertseifer, Alfred Morgenstern, Johannes Notni, Giovanni B. Giovenzana, Zsolt Baranyai
Abstract
Bi<sup>III</sup>-DOTP complex is characterised by a fast formation kinetics, an outstanding thermodynamic stability and an impressive kinetic interness, making Bi<sup>III</sup>-DOTP an optimal model for the development of targeted α-therapy (TAT) radiopharmaceuticals.
Topics & Concepts
ChemistryKineticsChemical reaction kineticsChemical kineticsRadiochemistryPhysical chemistryPhysicsQuantum mechanicsRadiopharmaceutical Chemistry and ApplicationsMedical Imaging Techniques and ApplicationsMedical Imaging and Pathology Studies