Differential Role of Serines and Threonines in Intracellular Loop 3 and C-Terminal Tail of the Histamine H<sub>4</sub> Receptor in β-Arrestin and G Protein-Coupled Receptor Kinase Interaction, Internalization, and Signaling
Eléonore W. E. Verweij, Betty Al Araaj, Wimzy R. Prabhata, Rudi Prihandoko, Saskia Nijmeijer, Andrew B. Tobin, Rob Leurs, Henry F. Vischer
Abstract
R interactions with these proteins is a first step in the understanding how this receptor might be dysregulated in pathophysiological conditions.
Topics & Concepts
InternalizationG protein-coupled receptor kinaseG protein-coupled receptorCell biologyBiologyBeta adrenergic receptor kinaseArrestinReceptorBiochemistryChemistrySignal transductionReceptor Mechanisms and SignalingMast cells and histamineNeuropeptides and Animal Physiology