Enantioselective Synthesis of 4-Allyl Tetrahydroquinolines via Copper(I) Hydride-Catalyzed Hydroallylation of 1,2-Dihydroquinolines
Qing‐Feng Xu‐Xu, Xiǎo Zhang, Shu‐Li You
Abstract
)-Ph-BPE-catalyzed asymmetric hydroallylation of 1,2-dihydroquinolines, prepared from readily available quinolines, was developed. The optically active tetrahydroquinolines (THQs) bearing an allylic functionality at position 4 were obtained in good yields and excellent enantioselectivity. The introduced allylic groups are amenable to diverse transformations, thus offering chances to rapidly expand the THQ libraries.
Topics & Concepts
ChemistryAllylic rearrangementEnantioselective synthesisCatalysisHydrideCombinatorial chemistryOptically activeOrganic chemistryMetalAsymmetric Hydrogenation and CatalysisOrganoboron and organosilicon chemistryCatalytic C–H Functionalization Methods