Litcius/Paper detail

Palladium-catalyzed double carbonylation of propargyl amines and aryl halides to access 1-aroyl-3-aryl-1,5-dihydro-2<i>H</i>-pyrrol-2-ones

Jun Ying, Zhengjie Le, Zhipeng Bao, Xiao‐Feng Wu

2020Organic Chemistry Frontiers18 citationsDOI

Abstract

A palladium-catalyzed carbonylative procedure for the synthesis of 1-aroyl-3-aryl-1,5-dihydro-2<italic>H</italic>-pyrrol-2-ones from propargyl amines and aryl halides with TFBen as the CO source has been developed.

Topics & Concepts

ChemistryArylCarbonylationPalladiumHalidePropargylCatalysisMedicinal chemistryOrganic chemistryCarbon monoxideAlkylCatalytic C–H Functionalization MethodsSynthesis and Characterization of PyrrolesCatalytic Alkyne Reactions