The intestinal microbial metabolite nicotinamide n-oxide prevents herpes simplex encephalitis via activating mitophagy in microglia
Feng Li, Yiliang Wang, Xiaowei Song, Zhaoyang Wang, Jiaoyan Jia, Shurong Qing, Lianzhou Huang, Yuan Wang, Shuai Wang, Zhe Ren, Kai Zheng, Yifei Wang
Abstract
. Together, these data demonstrate that gut microbial metabolites act as intrinsic restrictive factors against HSE progression via regulating mitophagy in microglia, implying further exploration of bacterial or nutritional approaches for treating neurotropic virus-related neurodegenerative diseases.
Topics & Concepts
BiologyMicrogliaImmune systemMitophagyMicrobiologyProinflammatory cytokineImmunologyInflammationAutophagyBiochemistryApoptosisNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersGut microbiota and health