Noninvasive stratification of nonalcoholic fatty liver disease by whole transcriptome cell-free mRNA characterization
Naga Chalasani, Shusuke Toden, John J. Sninsky, Richard P. Rava, Jerome V. Braun, Samer Gawrieh, Jiali Zhuang, Michael Nerenberg, Stephen R. Quake, Tara Maddala
2021American Journal of Physiology-Gastrointestinal and Liver Physiology31 citationsDOIOpen Access PDF
Abstract
This work is the first study, to our knowledge, to utilize circulating cell-free mRNA sequencing to develop an NAFLD diagnostic classifier.
Topics & Concepts
Nonalcoholic fatty liver diseaseFibrosisTranscriptomeLiver biopsySteatosisMedicineInternal medicineMessenger RNABiologyDiseaseBiopsyFatty liverGene expressionGeneBiochemistryLiver Disease Diagnosis and TreatmentCancer-related molecular mechanisms researchRNA modifications and cancer