LGP2 is essential for zebrafish survival through dual regulation of IFN antiviral response
Xiu-Ying Gong, Qi-Min Zhang, Xiang Zhao, Yilin Li, Zi-Ling Qu, Zhi Li, Cheng Dan, Jian‐Fang Gui, Yi-Bing Zhang
Abstract
at the late stage of viral infection. The function switch of LGP2 is related to cellular IFN production during viral infection. Our data demonstrate that zebrafish LGP2 is a key homeostatic regulator of IFN response and thus essential for zebrafish survival against SVCV infection.
Topics & Concepts
ZebrafishDual (grammatical number)BiologyComputational biologyGeneticsGenePhilosophyLinguisticsinterferon and immune responsesViral Infections and VectorsCancer-related molecular mechanisms research