Icariin attenuates perfluorooctane sulfonate-induced testicular toxicity by alleviating Sertoli cell injury and downregulating the p38MAPK/MMP9 pathway
Yan Zhang, Xiaoping Wu, Kaili Zhu, Shangyu Liu, Yuan Yang, Ding Yuan, Ting Wang, Yumin He, Yaoyan Dun, Jie Wu, Changcheng Zhang, Haixia Zhao
Abstract
. Furthermore, alleviation of the Sertoli cell injury by icariin exerted similar effects as SB203580 (an inhibitor of p38MAPK) in TM4 cells. This study revealed that icariin effectively reduces PFOS-induced testicular toxicity by alleviating the Sertoli cell injury and downregulating the p38MAPK/MMP9 pathway, indicating that icariin may be an attractive dietary supplement for the intervention of PFOS-induced testicular dysfunction.
Topics & Concepts
IcariinSertoli cellOccludinAndrologyChemistryToxicityEndocrinologyIn vivoTight junctionInternal medicineSpermatogenesisPharmacologyBiologyMedicineBiochemistryPathologyBiotechnologyAlternative medicineUrological Disorders and TreatmentsSperm and Testicular FunctionReproductive System and Pregnancy