Super-enhancer landscape reveals leukemia stem cell reliance on X-box binding protein 1 as a therapeutic vulnerability
Jingfeng Zhou, Shubo Wang, Danian Nie, Peilong Lai, Yiqing Li, Yangqiu Li, Yanli Jin, Jingxuan Pan
Abstract
conditional knockout suppressed the progression of CML and impaired the leukemogenesis of LSCs in CML mice. Overall, we identified an epigenetic transcriptional program in LSCs, adding to evidence for the theory of “oncogene addiction” and suggesting a potential targeting strategy for CML.
Topics & Concepts
BiologyXBP1Stem cellCancer researchChronic myelogenous leukemiaEpigeneticsTyrosine kinaseHaematopoiesisLeukemiaNilotinibImatinib mesylateCell biologyImatinibMyeloid leukemiaImmunologyGeneticsSignal transductionRNA splicingGeneRNAChronic Myeloid Leukemia TreatmentsProtein Degradation and InhibitorsChronic Lymphocytic Leukemia Research