An RNA editing strategy rescues gene duplication in a mouse model of MECP2 duplication syndrome and nonhuman primates
Dong Yang, Xiaoqing Wu, Yinan Yao, Mengsi Duan, Xing Wang, Guoling Li, Guo Ai-guo, Meixian Wu, Yuanhua Liu, Jin Zheng, Renxia Zhang, Tong Li, Alvin Luk, Xuan Yao, Linyu Shi, Chunlong Xu, Hui Yang
Topics & Concepts
MECP2Gene duplicationGene knockdownRett syndromeTransgeneBiologyRNAGeneGene expressionGene dosageGenetic enhancementNeuroscienceGeneticsPhenotypeGenetics and Neurodevelopmental DisordersRNA regulation and diseaseCRISPR and Genetic Engineering