Fe(III)/Bentonite as a Heterogeneous Catalyst for the Synthesis of 3,4‐dihydropyrimidin‐2‐(1H)‐ones
Lakha V. Chopda, Pragnesh N. Dave
Abstract
Abstract Fe(III) immobilized over natural bentonite (bent) using the impregnation method. Prepared catalysts were well characterized by XRD, FT‐IR and FeSEM. The catalytic activity of three catalysts 10, 20 and 30 % Fe(III)/bent evaluated for the synthesis of 3,4‐dihydropyrimidin‐2(1H)‐ones known as Biginelli reaction. The catalyst 30 % Fe(III)/bent exhibited a high yield of the product towards the synthesis of a variety of dihydropyrimidones (DHPMs). The high yield of dihydropyrimidone (DHPM) was obtained in model reaction in ethanol, acetonitrile, DMF and solvent ‐ free condition. The reusability test indicated that 6 % of yield of product decreased after 5 th cycle.
Topics & Concepts
CatalysisYield (engineering)BentoniteAcetonitrileReusabilityEthanolNuclear chemistrySolventChemistryMaterials scienceChemical engineeringOrganic chemistryMetallurgySoftwareProgramming languageEngineeringComputer scienceMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis and Characterization of Heterocyclic Compounds