Meganuclease targeting HSV-1 protects against herpetic keratitis: Application to corneal transplants
Benoît Chapellier, Damien Guindolet, Daniel de Souza Pereira, Román Galetto, José‐Alain Sahel, Marc Labétoulle, Éric Gabison
Abstract
into rabbit eyes protected against HSV-1 infection. This genome-editing technology targeting HSV-1 opens new opportunities to manage severe post-herpetic corneal blindness by providing infected patients with genetically protected corneal transplants.
Topics & Concepts
BiologyVirologyCorneaHerpes simplex virusEx vivoKeratitisIn vivoVirusGeneticsNeuroscienceHerpesvirus Infections and TreatmentsOcular Diseases and Behçet’s SyndromeCytomegalovirus and herpesvirus research