Editorial: Genetic and Immunologic Response in Kawasaki Disease
Ho‐Chang Kuo
Abstract
Topic enrolled articles of KD specific on the section of genetics and immune response from different nations or different areas that come from all over the world with the aim to get the immunopathogenic findings more clearly. The goal of this Research Topic is to provide more information about genetic or immunologic findings and even put them together to figure out the possibility of the etiology of KD from articles collected.There were 8 articles accepted for publication in this research topic including 64 authors, 3 original research, 1 brief research report, 1 mini review, 2 review, and 1 case report. The result from this report may explain the incidence of KD in Poland; however geographic distribution of gene polymorphisms in Polish children is unknown. Kuo et al. reported 24 healthy controls, 24 fever controls subjects and 49 KD subjects (with blood samples both before and after IVIG treatment) with total RNA from leukocytes and performed a quantitative polymerase chain reaction for the glycoprotein (HP, GRP84, and CLEC4D) genes in real time from Taiwan. The hyper-expression of these three genes was significantly associated with IVIG resistance, but not CAL formation.