PEG-interpenetrated genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier compound formulation for topical drug administration
Qijun Li, Shiqiang Gong, Weifan Yao, Yibin Yu, Chao Liu, Renjun Wang, Hao Pan, Minjie Wei
Abstract
dissolution profiles demonstrated that the increasement of PEG could accelerate the drug release rate. The compatibility of the drug delivery system was verified with cells and mice model. Topical delivery of ALA in solution, NLC and NLC-gel was investigated in-vitro.
Topics & Concepts
GenipinMaterials scienceBiocompatibilityEthylene glycolSelf-healing hydrogelsZeta potentialChitosanDrug deliveryChemical engineeringDispersityPEG ratioDrug carrierSolubilityChemistryNanoparticlePolymer chemistryOrganic chemistryNanotechnologyMetallurgyEconomicsFinanceEngineeringBiochemical Acid Research StudiesHydrogels: synthesis, properties, applicationsAdvancements in Transdermal Drug Delivery