Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody
Shenxin Zeng, Mingfei Wu, Yuyuan Jin, Yingqiao Ye, Heye Xia, Xinyi Chen, Jinxin Che, Zunyuan Wang, Ying Wu, Xiaowu Dong, Yinqiao Chen, Wenhai Huang, Wenhai Huang
Topics & Concepts
ChemistryJurkat cellsImmune systemKinaseCancer immunotherapyPharmacologyIC50T cellIn vivoImmunotherapyIn vitroBiochemistryImmunologyBiologyBiotechnologyMelanoma and MAPK PathwaysPeptidase Inhibition and AnalysisColorectal Cancer Treatments and Studies