Litcius/Paper detail

Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody

Shenxin Zeng, Mingfei Wu, Yuyuan Jin, Yingqiao Ye, Heye Xia, Xinyi Chen, Jinxin Che, Zunyuan Wang, Ying Wu, Xiaowu Dong, Yinqiao Chen, Wenhai Huang, Wenhai Huang

2024European Journal of Medicinal Chemistry17 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryJurkat cellsImmune systemKinaseCancer immunotherapyPharmacologyIC50T cellIn vivoImmunotherapyIn vitroBiochemistryImmunologyBiologyBiotechnologyMelanoma and MAPK PathwaysPeptidase Inhibition and AnalysisColorectal Cancer Treatments and Studies