Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies
Kanak Raina, Chris D. Forbes, Rebecca Stronk, Jonathan P. Rappi, Kyle J. Eastman, Nilesh Zaware, Xinheng Yu, Hao Li, Amit Bhardwaj, Samuel W. Gerritz, Mia Forgione, Abigail Hundt, Madeline P. King, Zoe Posner, Allison D. Correia, Andrew McGovern, D.E. Puleo, Rebekka Chenard, James J. Mousseau, J. Ignacio Vergara, Ethan Garvin, Jennifer Macaluso, Michael Martin, Kyle Bassoli, Kelli Jones, Marco Garcia, Katia Howard, Madeleine Yaggi, Levi M. Smith, Jinshan M. Chen, Andrew B. Mayfield, Cesar A. De Leon, John Hines, Katherine J. Kayser-Bricker, Craig M. Crews
Topics & Concepts
EffectorSmall moleculeCell biologyChemical biologyCancer cellBiologyIntracellularTarget proteinChimera (genetics)Cyclin-dependent kinaseFKBPLinkerProtein–protein interactionCancer researchChemistryBiochemistryCancerCellCell cycleGeneticsGeneComputer scienceOperating systemProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments