Strategies to Optimize Treatment for Locally Advanced Rectal Cancer
Xiaoyu Hu, Zhuang Xue, Kewen He, Yaru Tian, Yu Chen, Mengyu Zhao, Jinming Yu, Jinbo Yue
Abstract
Neoadjuvant long-course concurrent chemoradiation plus surgery, followed by optional adjuvant chemotherapy, is a standard of care for locally advanced rectal cancer (LARC). However, this traditional approach has several limitations, including low pathological complete response (pCR) (10-25%), high metastasis rate (30-35%), and highly inconsistent compliance with adjuvant chemotherapy (25-75%). Treatment modalities for LARC have dramatically evolved in recent years. Multiple clinical trials have focused on optimizing strategies to achieve a win-win situation for oncologic outcomes and functions. Here, we review the latest studies into optimizing neoadjuvant treatment for LARC.