Small molecule inhibitor of TAK1 ameliorates rat cartilaginous endplate degeneration induced by oxidative stress in vitro and in vivo
Pan Tang, Wenxiang Chen, Hongliang Gao, Jiayong Dai, Yu Gu, Ziang Xie, Xiongfeng Li, Shun-Wu Fan, Xuesheng Jiang, Qian Lü, Zhijun Hu
Topics & Concepts
In vivoOxidative stressIn vitroChemistryDegeneration (medical)CatabolismCell biologyViability assayBiochemistryBiologyEnzymePathologyMedicineBiotechnologyNF-κB Signaling PathwaysOsteoarthritis Treatment and MechanismsInflammatory mediators and NSAID effects