One simple Ir/hydrosilane catalytic system for chemoselective isomerization of 2-substituted allylic ethers
Weiwei Gao, Xueyan Zhang, Xingze Xie, Shengtao Ding
Abstract
Here, we describe one simple Ir/hydrosilane catalytic system for chemoselective isomerization of 2-substituted allylic ethers. This facile strategy shows high efficiency towards a variety of substrates, including derivatives from bioactive molecules. The substituent at the α position of the olefins is supposed to be critical in retarding the alkene hydrosilylation process and leading the reaction to go through the isomerization pathway.
Topics & Concepts
IsomerizationAllylic rearrangementHydrosilylationSubstituentChemistryCatalysisAlkeneOrganic chemistryCombinatorial chemistryPhotochemistryOrganoboron and organosilicon chemistryChemical Synthesis and AnalysisAsymmetric Hydrogenation and Catalysis