NLRP3 inflammasome and bruton tyrosine kinase inhibition interferes with upregulated platelet aggregation and in vitro thrombus formation in sickle cell mice
Sebastian Vogel, Sayuri Kamimura, Taruna Arora, Meghann L. Smith, Luis E.F. Almeida, Christian A. Combs, Swee Lay Thein, Zenaide Quezado
Topics & Concepts
Bruton's tyrosine kinaseInflammasomeDownregulation and upregulationPlateletTyrosine kinaseChemistryPlatelet activationIn vitroPharmacologyImmunologyIbrutinibCancer researchProto-oncogene tyrosine-protein kinase SrcMedicineReceptorBiochemistryLeukemiaChronic lymphocytic leukemiaGeneHemoglobinopathies and Related DisordersErythrocyte Function and PathophysiologyMyeloproliferative Neoplasms: Diagnosis and Treatment