Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins
Ya‐Hui Chi, Teng‐Kuang Yeh, Yi‐Yu Ke, Wen‐Hsing Lin, Chia‐Hua Tsai, Wan-Ping Wang, Yen‐Ting Chen, Yu‐Chieh Su, Peichen Wang, Yan-Fu Chen, Zhong-Wei Wu, Jen-Yu Yeh, Ming‐Chun Hung, Mine-Hsine Wu, Jingya Wang, Ching-Ping Chen, Jen‐Shin Song, Chuan Shih, Chiung‐Tong Chen, Chun‐Ping Chang
Abstract
-amplified cancers including SCLC.
Topics & Concepts
ProdrugAurora kinaseChemistryKinaseAurora inhibitorPharmacokineticsCancer researchAurora A kinasePyrimidinePharmacologySmall moleculeIC50Cell growthDownregulation and upregulationLead compoundCellIn vitroBiochemistryCell cycleBiologyGeneMicrotubule and mitosis dynamicsProtein Degradation and InhibitorsLung Cancer Research Studies