Increased Expression of Efflux Pump <i>norA</i> Drives the Rapid Evolutionary Trajectory from Tolerance to Resistance against Ciprofloxacin in Staphylococcus aureus
Xiaohui Yu, Zehua Hao, P L Liu, M. M. Liu, Lixiu Zhao, Xin Zhao
Abstract
experiment. This study illustrated the role of efflux pumps in the evolutionary trajectory from tolerance to resistance. The delayed resistance development caused by the efflux pump inhibitor illuminates a possible strategy for postponing the resistance acquisition from tolerance to resistance by disrupting efflux pumps.
Topics & Concepts
EffluxCiprofloxacinMicrobiologyBiologyStaphylococcus aureusMultidrug toleranceAntibioticsPopulationDrug resistanceGeneticsBacteriaMedicineBiofilmEnvironmental healthAntimicrobial Resistance in StaphylococcusAntibiotic Resistance in BacteriaCancer therapeutics and mechanisms