HPMA nanomedicine: targeting cancer with precision
Sarita Rani, Vinay Kumar, Sofiya Tarannum, Umesh Gupta
Abstract
-2 hydroxypropyl methacrylamide), polyethylene, polystyrene, and other compounds have been extensively used for drug delivery. This review highlights the importance of pHPMA in nanodrug delivery. First, we review the chemical properties, pharmacology, and pharmacokinetics of pHPMA, followed by its synthetic routes of preparation. Second, we discuss pHPMA-based nanocarriers and their therapeutic efficacy in cancer. In addition, we present the clinical status and future prospects of pHPMA in combination with immunotherapy. We aim to provide comprehensive insights into the current pHPMA nanotherapeutics to facilitate future development.
Topics & Concepts
NanomedicineCancerNanotechnologyMaterials scienceMedicineNanoparticleInternal medicineNanoparticle-Based Drug DeliveryGraphene and Nanomaterials ApplicationsRNA Interference and Gene Delivery